antibiogram of methicillin-resistant staphylococcus aureus isolates from mrsa colonized patients in two tertiary hospital emergency departments

conclusions the average value of the vancomycin mic for isolates from mrsa colonized patients was 2 µg/ml. trimethoprim /sulfamethoxazole was the second most effective anti-mrsa oral antibiotic in vitro. patients and methods from november 2009 to march 2011, a prospective study was performed in two emergency departments. patients at high risk for mrsa colonization were identified, and mrsa surveillance cultures obtained. the mic for anti-mrsa antibiotics in cultures from each patient was evaluated. results a total of 276 patients were assessed. of these, 23.6% (65/276) were mrsa culture positive. the mic 50 and mic 90 for vancomycin with these mrsa isolates by e-test were both 2 µg/ml. the mic 50 and mic 90 for teicoplanin were 2 µg/ml and 3 µg/ml, respectively, among mrsa isolates. nearly all (62/65, 95.4%) mrsa isolates were sensitive to trimethoprim /sulfamethoxazole. of all patients, 47.7% (31/65) of the mrsa isolates were sensitive to gentamicin, 40% (26/65) to minocycline, 13.8% (9/65) to clindamycin, 6.2% (4/65) to erythromycin, and 1.5% (1/65) to levofloxacin. background methicillin-resistant staphylococcus aureus (mrsa) colonized patients are at increased risk of developing mrsa infections. objectives this study was undertaken to evaluate the minimum inhibitory concentration (mic) of anti-mrsa antibiotics for mrsa isolates from mrsa colonized patients.